• SIAIS Special Seminars| Decrypting the Noncoding Genome: Unmasking the role of enhancers in human disease

    发布者:冯明静发布时间:2019-12-30浏览次数:31

    Speaker: Dr. Bing Ren

    Host: Dr. Hanhui Ma and Dr. Ge Jiang

    Time: 13:00-14:00, Friday, Jan 3, 2020

    Venue: Auditorium, Y Building



    Abstract

    A large number of sequence variants have been linked to complex traits and disease through genome-wide association studies, but deciphering their biological function is still challenging because most of them reside in noncoding DNA, where functional annotation is still lacking. A growing list of studies has shown that noncoding risk variants may contribute to human disease by perturbing the transcriptional regulatory sequences.  However, it is still unclear whether this mechanism generally applies to the tens of thousands of risk variants identified to date.  Efforts to address this question have been hampered by an incomplete understanding of the transcriptional regulatory sequences in the genome.   Here, I will present our recent progress in the mapping and functional characterization of transcriptional regulatory sequences in the human and mouse genomes.  I will discuss the development of highly predictive models for assessing the impact of sequence variants on DNA binding of transcription factors.  I will also describe how mapping the long-range chromatin interactions allows us to infer the target genes of noncoding risk variants in Alzheimer’s disease and other common diseases.    



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