•   王权 博士

    助理教授 课题组长

    所在学院 免疫化学研究所

                  生命科学与技术学院

    研究方向 微生物生物能量代谢系统组成与结构;真核细胞线粒体与天然免疫;冷冻电子显微学

    联系方式  wangq@@shanghaitech.edu.cn


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    个人简介

    2009年本科毕业于南开大学信息技术与科学学院;

    2014年博士毕业于南开大学生命科学学院;

    2014年至2018年在中国科学院生物物理研究所任助理研究员;

    2014年至2015年在牛津大学牛津粒子成像中心访问;

    2018年至2019年在中国科学院生物物理研究所任副研究员;

    2019年至2020年在中国科学院生物物理研究所任研究员、课题组长;

    2020年2月加入上??萍即笱蒲в爰际跹г?免疫化学研究所任助理教授、研究员。


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    主要研究内容

    致力于利用冷冻电子显微等成像技术,在多尺度下研究结核分枝杆菌、幽门螺旋杆菌等病原微生物能量代谢系统的分子组成、结构特征与功能机制,以及真核细胞“能量工厂”-线粒体在调节宿主天然免疫应对病原菌感染过程中的作用。同时,亦通过干预生物能量代谢系统,开展抗耐药菌和抗肿瘤的药物筛选与研发工作。相关成果在Science、PNAS等国际期刊发表。


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    代表性论文

    Structural Biology

    1.    Hongri Gong#; Jun Li#; Ao Xu#; Yanting Tang; Wenxin Ji; Ruogu Gao; Shuhui Wang; Lu Yu; Changlin Tian; Jingwen Li; Hsin Yung Yen; Sin Man Lam; Guanghou Shui; Xiuna Yang; Yuna Sun; Xuemei Li; Minze Jia; Cheng Yang; Biao Jiang; Zhiyong Lou; Carol V Robinson; Luet Lok Wong; Luke W Guddat; Fei Sun*; Quan Wang*; Zihe Rao*, An electron transfer path connects subunits of a mycobacterial respiratory supercomplex , Science, 2018.10.25, 362(6418): 0~eaat8923 [Representative Publication, Co-corresponding Author]

    2.    Wenxia Liu#; Aijun Liu; Hailong Gao; Quan Wang; Limin Wang; Eberhard Warkentin; Zihe Rao; Hartmut Michel*; Guohong Peng*, Structural properties of the peroxiredoxin AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus, Biochimica et Biophysica Acta-General Subjects, 2018.12, 1862(12): 2797~2805

    3.    Kotecha Abhay#; Wang Quan; Dong Xianchi; Ilca Serban L; Ondiviela Marina; Zihe Rao; Seago Julian; Charleston Bryan; Fry Elizabeth E; Abrescia Nicola G A; Springer Timothy A*; Huiskonen Juha T*; Stuart David I*, Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus, Nature Communications, 2017.05.23, 8: 0~15408

    4.    Dang, Minghao#; Wang, Xiangxi; Wang, Quan; Wang, Yaxin; Lin, Jianping; Sun, Yuna; Li, Xuemei; Zhang, Liguo; Lou, Zhiyong; Wang, Junzhi; Rao, Zihe*, Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71., Protein & Cell, 2014.9, 5(9): 692~703

    5.    Li, Baobin#; Wang, Quan#; Pan, Xijiang; Fernandez de Castro, Isabel; Sun, Yuna; Guo, Yu; Tao, Xinwei; Risco, Cristina; Sui, Sen-Fang; Lou, Zhiyong*, Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation., Proceedings of the National Academy of Sciences of the United States of America, 2013.05.28, 110(22): 9048~9053 [Representative Publication, Co-first Author]

    6.    Chen, Qingfeng#; Chen, Xiangsong#; Wang, Quan; Zhang, Faben; Lou, Zhiyong*; Zhang, Qifa*; Zhou, Dao-Xiu*, Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice., PLoS Genetics, 2013, 9(1)

    7.    Chen, Qingfeng#; Wang, Quan; Xiong, Lizhong*; Lou, Zhiyong*, A structural view of the conserved domain of rice stress-responsive NAC1., Protein Cell, 2011.1, 2(1): 55~63

    8.    Wang, Hui#; Morita, Masahiro; Yang, Xiuna; Suzuki, Toru; Yang, Wen; Wang, Jiao; Ito, Kentaro; Wang, Quan; Zhao, Cong; Bartlam, Mark*; Yamamoto, Tadashi*; Rao, Zihe, Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity., The EMBO Journal, 2010.8.4, 29 (15): 2566~2576


    Drug Discovery

    9.    Dong, Jing#; Zhang, Yong; Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Yang, Cheng; Wang, Quan; Li, Xuemei*; Deng, Xuming*, Baicalin inhibits the lethality of Shiga-like toxin 2 in mice., Antimicrobial Agents and Chemotherapy, 2015.11, 59(11): 7054~7060

    10.Cao, Shujuan#; Yu, Liang; Mao, Jingyuan; Wang, Quan; Ruan, Jishou*, Uncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network., PLos One, 2015, 10(12)

    11.Shanshan Qin#; Yiran Ren#; Xu Fu; Jie Shen; Xin Chen; Quan Wang; Xin Bi; Wenjing Liu; Lixin Li; Guangxin Liang; Cheng Yang; Wenqing Shui*, Multiple ligand detection and affinity measurement by ultrafiltration and mass spectrometry analysis applied to fragment mixture screening, Analytica Chimica Acta, 2015.7.30, 886: 98~106

    12.Chen, Xin#; Qin, Shanshan; Chen, Shuai; Li, Jinlong; Li, Lixin; Wang, Zhongling; Wang, Quan; Lin, Jianping; Yang, Cheng; Shui, Wenqing*, A ligand-observed mass spectrometry approach integrated into the fragment-based lead discovery pipeline., Scientific Reports, 2015, 5: 8361~8361

    13.Dong, Jing#; Zhang, Yong; Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Li, Rui; Yang, Cheng; Wang, Quan; Li, Xuemei; Deng, Xuming*, Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization., Journal of Biological Chemistry, 2015.5.15, 290(20): 12899~12907

    14. Dazhi Liu#; Zhen Tian; Zhihui Yan; Lixin Wu; Yan Ma; Quan Wang; Wei Liu*; Honggang Zhou; Cheng Yang, Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors, Bioorganic & Medicinal Chemistry, 2013.6.1, 21(11): 2960~2967 



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